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MAIN RESEARCHER
 
   Kozo Shishido
Phone :   +81-88-633-7287
Fax :   +81-88-633-7287
E-Mail :  shishido@ph.tokushima-u.ac.jp
Postal Adress :  1-78 Sho-machi, Tokushima 770-8505, Japan
Brief C.V.: 
Ph.D(1976, Tohoku University, Prof. Tetsuji Kametani) 
Post Doc. (1978-1979, Dept. of Chemistry,Texas A&M University, Prof. A. I. Scott) 
Post Doc. (1979-1980, Dept. of Chemistry, UCLA, Prof.M. E. Jung) 
Assistant Professor (1972-1989, Tohoku University) 
Associate Professor (1989-1993, University of Tokushima) 
Professor (1994-, University of Tokushima)
Personal Interests: 
jogging


RESEARCH GROUP
 
   Laboratory of Synthetic Organic Chemistry
Phone :  +81-88-633-7287
Fax :  +81-88-633-7287
Postal Adress :  1-78 Sho-machi, Tokushima 770-8505, Japan
Link:  http://www.ph.tokushima-u.ac.jp
Research Area: 
 Total synthesis of biologically active natural products, development of new synthetic reactions
References: 
1. Selective Cleavage of the Trisubstituted Cyclopropanes via Cyclopropylcarbinyl Radical Fragmentation. Y. Takekawa, K. Shishido, Tetrahedron Lett. in press. 
2.A Novel Tandem [2+2]Cycloaddition-Dieckmann Condensation: Facile One-Pot Process to Obtain 2,3-Disubstituted-2-cycloalkanones from Ynolates. M. Shindo, Y. Sato, K. Shishido, J. Am. Chem. Soc., 1999, 121, 6507-6508. 
3. Cycloaddition of Lithium Ynolate to Imines: Synthesis of 3,4-Disubstituted b-Lactams. M. Shindo, S. Oya, Y. Sato, K. Shishido, Heterocycles, 1998, 49, 113-116. 
4. Synthesis and Evaluation of Enantiomerically Pure Azinomycin-Lexitropsin Hybrid Molecules with DNA-Cleaving Activity.K. Shishido, S. Haruna, H. Iitsuka, M. Shibuya, Heterocycles, 1998, 49, 109-112. 
5. Novel and General Entry into Pseudoguaianolides. Formal and Enantioselective Synthesis of (+)-Confertin.M. Ohtsuka, Y. Takekawa, K. Shishido, Tetrahedron Lett., 1998, 39, 5803-5806. 
6. Lipase-mediated Asymmetric Acetylation of Prochiral Diols Directed Towards Total Syntheses of Biologically Active Molecules. K. Shishido, T. Bando, J. Mol. Cat. B: Enzymatic, 1998, 5, 183-186. 
7. Novel synthesis of Ynolates via the Cleavage of Ester Dianions: a-Bromo and a,a-Dibromo Esters as Precursors. M. Shindo, Y. Sato, K. Shishido, Tetrahedron, 1998, 54, 2411-2422. 
8. Synthesis and Evaluation of the Hybrid Molecules Possessing DNA-Cleaving Activity. K. Shishido, S. Haruna, C. Yamamura, H. Iitsuka, H. Nemoto, Y. Shinohara, M. Shibuya, Bioorg. & Med. Chem. Lett., 1977, 7(20), 2617-1622. 
9. A General Asymmetric Access to the Podocarpane Diterpenoids. Y. Fujiwara, T. Yamato, T. Bando, K. Shishido, Tetrahedron:Asymmetry, 1997, 8(16), 2793-2799. 
10.New Asymmetric Cosntruction of the Benzylic Quaternary Stereogenic Centre: An Enantiocontrolled Access to (-)-a-Cuparenone. T. Kosaka, T. Bando, K. Shishido, Chem. Commun., 1997, 1167-1168.


DEPARTMENT
 
   Institute for Medicinal Resources
Phone :  +81-88-633-7287
Fax :  +81-88-633-7287
Postal Adress :  1-78 Sho-machi, Tokushima 770-8505, Japan


UNIVERSITY / COMPANY
 
   University of Tokushima
Phone :   +81-88-631-3111
Fax :   +81-88-633-9517
Postal Adress :   1-78 Sho-machi, Tokushima 770-8505, Japan